Istradefylline forty mg/day enhanced peak levels and AUC of CYP3A4 substrates in scientific trials. This result was not observed with istradefylline 20 mg/day. Take into account dose reduction of delicate CYP3A4 substrates.modafinil will lower the extent or effect of mavacamten by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicat
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